Many clinicians expect complete healing after the removal of temporary anchorage devices, but clinical examination may reveal scar-like tissue. This report presents the typical features of scarring detected after the removal of miniscrews, and the clinical outcome of scar revision along with its pathologic features.
Cicatrix* ; Wound Healing

No abstract available.
Wound Healing

BACKGROUND: The degree of scar formation varies according to the sites. Oral mucosa heals faster with lesser scar formation than skin and it is very rare for oral mucosa to develop hypertrophic scars. Collagen gel seeded with fibroblasts is considered as a valuable model for studying wound healing in vitro. OBJECTIVE: The purpose of this study was to find out whether there are any differences in contractiliy of collagen gel by fibroblasts derived from different sites. METHODS: Fibroblasts were cultured from normal skin, oral mucosa, and hypertrophic scar. They were seeded into collagen gel with or without serum, and the degree of contraction of the collagen gel was measured for 5 days. RESULTS: Hypertrophic scar fibroblasts in collagen gel possessed the greatest contraction potency followed by normal skin fibroblasts and oral mucosal fibroblasts. Serum significantly increased the contractility of each of the fibroblasts. The differences of contractility of collagen gel between oral mucosal fibroblasts and others became more obvious in the presence of serum, however, those between normal skin fibroblasts and hypertrophic scar fibroblasts became less obvious. CONCLUSION: The degree of contraction of collagen gel by fibroblasts correlated with the degree of scar formation. Addition of serum modified the degree of contractile potency which may reflect the differences in the fibroblasts with phenotypic alteration and the subtype of fibroblasts.
Cicatrix ; Cicatrix, Hypertrophic* ; Collagen* ; Fibroblasts* ; Mouth Mucosa* ; Skin* ; Wound Healing

Keloids are fibrous overgrowth resulting from abnormal wound healing processes at the site of cutaneous injury. It extends beyond the confines of the original wound, begins later after injury, and does not regress with time contrary to hypertrophic scar. The gold standard has not been established in the treatment of keloids, yet. Excision of keloid alone showed a high rate of recurrence (45-100%). Recently, we have experienced two keloidal masses in the auricle (one on helix, the other on lobule), which were treated with surgery and adjuvant steroid injection. We developed an anteriorly-based skin flap from the skin covering of the keloidal mass and used it for several reasons. We also used triamcinolone injection after the surgery. In this paper, we are presenting the result of these cases with a review of literature.
Cicatrix, Hypertrophic ; Keloid* ; Recurrence ; Skin ; Triamcinolone ; Wound Healing ; Wounds and Injuries

PURPOSE: The mechanism of scar formation is not fully understood. Fibroblast is an important cell in wound healing process. We experienced a patient who was taking progesterone orally. Upper blepharoplasty was performed on her but, wound healing was delayed. We hypothesized that progesterone was the cause of delayed wound healing and fibroblast proliferation inhibition. We investigated the effect of progesterone in vitro on human dermal fibroblasts to study the effects on fibroblast proliferation. METHODS: Human dermal fibroblasts from four persons were cultured initially. Progesterone is mixed to them at various concentrations, and fibroblast cell count was measured by MTT assay method at 570nm. We confirmed that progesterone has some inhibitory effect on fibroblast proliferation and maximal inhibitory concentration of progesterone was determined. Then fibroblasts from a total of nineteen persons were cultured and the effects of progesterone were studied. RESULTS: The initial study showed the maximal inhibitory concentration of progesterone to be 50 microgram/ml. The main study showed that progesterone had 70.9% inhibitory effect on human dermal fibroblast in vitro. CONCLUSION: Progesterone has inhibitory effect on cultured human dermal fibroblast proliferation in vitro.
Blepharoplasty ; Cell Count ; Cicatrix ; Fibroblasts* ; Humans* ; Progesterone* ; Wound Healing

No abstract available.
Wound Healing* ; Wounds and Injuries*

No abstract available.
Wound Healing ; Wounds and Injuries

No abstract available.
Wound Healing ; Wounds and Injuries

BACKGROUND: Because cosmetic laser treatments are getting popular, post-laser wound care becomes more important. Currently, topical moisturizers are reported to be sufficient to accelerate re-epithelialization and reduce downtime in post-laser wound care. OBJECTIVE: This study was performed to evaluate the effects of the moisturizer APDDR-1001 for post-laser wound care, after ablative fractional laser on the face. METHODS: In this double-blind, split-face study, 41 patients with photo-aged face received ablative fractional laser. They were divided into two groups, APDDR-1001 and vehicle (group 1) or control moisturizer (group 2), which were applied to the opposite sides of the face for 1 week after the laser treatment. The treatment efficacy was evaluated by the transepidermal water loss (TEWL), erythema index, investigator's assessment for recovery in erythema and overall improvement of the wound. Subjects ranked irritating symptoms and overall satisfaction ratings in the overall improvement. RESULTS: APDDR-1001 was well-tolerated and showed improvement in the erythema index and TEWL during the 7 days of treatment. In group 2, improvement in erythema graded by investigators was significantly higher for APDDR-1001 on day 3 (p<0.05). The overall improvement of wound ranked by investigators was significantly higher for APDDR-1001, compared with the controls in both groups. Subjective assessment demonstrated significantly less erythema (p=0.043), edema (p=0.041) and overall satisfaction ratings in the overall improvement (p<0.048) with APDDR-1001; however, no differences were detected in pain and edema between APDDR-1001 and vehicle (group 1). In group 2, subjects ranked 'much or very much improved' in 75 % of APDDR-1001 side and 55% of control moisturizer side. No significant differences in erythema, edema, pain and itching were reported between APDDR-1001 and control moisturizer in group 2. CONCLUSION: The moisturizer APDDR-1001 demonstrated effective improvements in wound healing and subjective symptoms after ablative fractional laser therapy.
Cosmetics ; Edema ; Erythema ; Humans ; Laser Therapy ; Pruritus ; Re-Epithelialization ; Research Personnel ; Treatment Outcome ; Wound Healing

PURPOSE: This study was planned to evaluate the effect of plant extracts contained dressing material which is rich in procyanidins for treatment of deep second degree burn. METHODS: This study conducted from September 1, 2013 to February 28, 2014. Patients with the deep dermal burn wound which is larger than 200 cm2 were enrolled in this study. The test material was applied total 3 times every 2 days when the wounds were relatively clean, with thin eschar and scab removed and the dermal layer exposed. The test and control sites were treated with hydro-foam equally. The effectiveness was evaluated by comparing the re-epithelialization rates between the test and control sites. Two burn surgeons blindly evaluated for re-epithelialization. Evaluation of adverse reaction was also performed during study period. RESULTS: Total of 40 patients were enrolled. Mean total body surface area burned% was 12.3+/-5.5% and the test material was first applied at mean post burn day # 7.2+/-2.0.The re-epithelialization period was 9.0+/-1.7 days in the test site and 11.1+/-2.0 days in the control site. In the test site, re-epithelialization was 2.1+/-1.0 days faster than in the control site (P<0.0001). There was no significant adverse reaction during study period. CONCLUSION: The plant extracts contained dressing material which is rich in procyanidins accelerates wound healing time and shows the safety.
Bandages* ; Body Surface Area ; Burns* ; Humans ; Plant Extracts* ; Proanthocyanidins* ; Re-Epithelialization ; Wound Healing ; Wounds and Injuries