Dermatofibrosarcoma protuberans is an unusual locally aggressive cutaneous neoplasm of low grade malignancy. We report the case of a 47 years- old male who presented with an asymptomatic erythematous firm protruding mass in the left peri-inguinal area. Histopathologically, the tumor showed spindle-shape cells, arranged in a storiform pattern. The tumor cells stained positively for Vimentin and CD34 on immunohistochemical staining. Herein, we report a case of dermatofibrosarcoma protuberans.
Dermatofibrosarcoma ; Humans ; Male ; Vimentin

Microcystic stromal tumor (MCST) of the ovary is a rare subtype of ovarian tumor first described in 2009. Although high nuclear expression of β-catenin and β-catenin gene (CTNNB1) mutation are related with ovarian MCST, the origin and genetic background of ovarian MCST remain unclear. In this study, two cases of ovarian MCST are presented. Microscopically, the tumors showed a microcystic pattern and regions with lobulated cellular masses with intervening hyalinized, fibrous stroma. Tumor cells of both cases were stained with CD10, vimentin, and Wilms tumor 1. Genetic analysis was performed and β-catenin gene (CTNNB1) mutation in exon 3 was detected in both cases. This is the first report in regards of detecting CTNNB1 mutation in ovarian MCST through the use of pyrosequencing (a novel sequencing technique).
Exons ; Female ; Hyalin ; Ovary ; Vimentin ; Wilms Tumor

Microcystic stromal tumor (MCST) of the ovary is a rare subtype of ovarian tumor first described in 2009. Although high nuclear expression of β-catenin and β-catenin gene (CTNNB1) mutation are related with ovarian MCST, the origin and genetic background of ovarian MCST remain unclear. In this study, two cases of ovarian MCST are presented. Microscopically, the tumors showed a microcystic pattern and regions with lobulated cellular masses with intervening hyalinized, fibrous stroma. Tumor cells of both cases were stained with CD10, vimentin, and Wilms tumor 1. Genetic analysis was performed and β-catenin gene (CTNNB1) mutation in exon 3 was detected in both cases. This is the first report in regards of detecting CTNNB1 mutation in ovarian MCST through the use of pyrosequencing (a novel sequencing technique).
Exons ; Female ; Hyalin ; Ovary ; Vimentin ; Wilms Tumor

Degeneration and transformation of lens epithelial cells (LECs) have been regarded as major causes of cataract and after-cataract. So behaviors of LECs have been studied in order to prevent some kinds of cataract and after-cataract, mainly in vitro. This study identified in vivo that human LECs beneath the anterior capsule were transformed in anterior polar type of cataract. Normal LECs showed positive staining for both cytokeratin and virnentin, while transformed LECs in the anterior polar type of cataractous lens were positive for vimentin only. Additionally, these transformed LECs seern to be fibrocytes without cellular junctions, are vertically or obliquely oriented, and spindle-shaped. These cells were embedded within 8 fibrillar meshwork rnass secreted by themselves. With this result it was found that LECs could be transformed into fibroblat like cells and this transformation of LECs were observed in anterior polar type of cataractous lens.
Cataract ; Epithelial Cells ; Humans ; Keratins ; Vimentin

Degeneration and transformation of lens epithelial cells (LECs) have been regarded as major causes of cataract and after-cataract. So behaviors of LECs have been studied in order to prevent some kinds of cataract and after-cataract, mainly in vitro. This study identified in vivo that human LECs beneath the anterior capsule were transformed in anterior polar type of cataract. Normal LECs showed positive staining for both cytokeratin and virnentin, while transformed LECs in the anterior polar type of cataractous lens were positive for vimentin only. Additionally, these transformed LECs seern to be fibrocytes without cellular junctions, are vertically or obliquely oriented, and spindle-shaped. These cells were embedded within 8 fibrillar meshwork rnass secreted by themselves. With this result it was found that LECs could be transformed into fibroblat like cells and this transformation of LECs were observed in anterior polar type of cataractous lens.
Cataract ; Epithelial Cells ; Humans ; Keratins ; Vimentin

Degeneration and transformation of lens epithelial cells (LECs) have been regarded as major causes of cataract and after-cataract. So behaviors of LECs have been studied in order to prevent some kinds of cataract and after-cataract, mainly in vitro. This study identified in vivo that human LECs beneath the anterior capsule were transformed in anterior polar type of cataract. Normal LECs showed positive staining for both cytokeratin and virnentin, while transformed LECs in the anterior polar type of cataractous lens were positive for vimentin only. Additionally, these transformed LECs seern to be fibrocytes without cellular junctions, are vertically or obliquely oriented, and spindle-shaped. These cells were embedded within 8 fibrillar meshwork rnass secreted by themselves. With this result it was found that LECs could be transformed into fibroblat like cells and this transformation of LECs were observed in anterior polar type of cataractous lens.
Cataract ; Epithelial Cells ; Humans ; Keratins ; Vimentin

Degeneration and transformation of lens epithelial cells (LECs) have been regarded as major causes of cataract and after-cataract. So behaviors of LECs have been studied in order to prevent some kinds of cataract and after-cataract, mainly in vitro. This study identified in vivo that human LECs beneath the anterior capsule were transformed in anterior polar type of cataract. Normal LECs showed positive staining for both cytokeratin and virnentin, while transformed LECs in the anterior polar type of cataractous lens were positive for vimentin only. Additionally, these transformed LECs seern to be fibrocytes without cellular junctions, are vertically or obliquely oriented, and spindle-shaped. These cells were embedded within 8 fibrillar meshwork rnass secreted by themselves. With this result it was found that LECs could be transformed into fibroblat like cells and this transformation of LECs were observed in anterior polar type of cataractous lens.
Cataract ; Epithelial Cells ; Humans ; Keratins ; Vimentin

Rudimentary meningocele, also known as a 'variant of primary cutaneous meningioma' or 'acoelic meningeal hamartoma', is an unusual developmental anomaly in which meningothelial elements are found in the skin. A 8-month-old girl has a well-circumscribed, alopecic, atrophic patch on the midline of the occipital area since birth. Histologically, pseudovascular spaces lined with flattened or cuboidal cells were seen in the papillary and upper reticular dermis without collagen bodies. These flattened or cuboidal cells were positive for vimentin, but negative for EMA, immunohistochemically. Radiographic finding of the scalp revealed no underlying bony defect.
Collagen ; Dermis ; Female ; Humans ; Infant ; Meningocele* ; Parturition ; Scalp ; Skin ; Vimentin

Malignant glomus tumor, or glomangiosarcoma, is a very rare neoplasm that typically arises from a benign glomus tumor. Despite having the histological features of malignancy, these tumors usually do not metastasize. We report a case of malignant glomus tumor on the finger of an 18-year-old man. By histology, round to ovoid tumor cells showed a uniform appearance of round nuclei. Many mitotic figures and nuclear atypia were observed. Immunohistochemically, vimentin and alpha-smooth muscle actin showed intense staining. This case was considered to be a malignant glomus tumor. Thus, it was a glomangiosarcoma arising de novo.
Actins ; Adolescent ; Fingers ; Glomus Tumor ; Humans ; Muscles ; Vimentin

Solitary fibrous tumor is an uncommon mesenchymal neoplasm that can arise in both pleura and extrapleural locations. This tumor is composed of spindled cells intimately admixed with collagen bundles that are arranged in a 'patternless pattern'. Immunohistochemically, the tumor cells strongly express CD34 and vimentin. This tumor can mimic a variety of benign and malignant mesenchymal tumors. Rare cases of primary cutaneous solitary fibrous tumor have recently been reported and they have been added to an increasing variety of mesenchymal tumors that may primarily arise in the skin. We present here a case of primary cutaneous solitary fibrous tumor and we briefly review the relevant literature.
Collagen ; Hydrazines ; Pleura ; Scalp ; Skin ; Solitary Fibrous Tumors ; Vimentin