The discrimination of eccrine and apocrine neoplasms is still in dispute among researchers. To discriminate the differentiation of eccrine and apocrine neoplasms, immunohistochemical stainings with HMFG-1 and GCDFP-15 were performed on 12 specimens of eccrine and apocrine neoplasms, 3 of normal palmar tissues, and 3 of normal axillary tissues. The 12 cases of eccrine and apocrine neoplasms included 3 cases of syringoma, 2 cases of eccrine poroma, 2 cases of hidradenoma, 2 cases of apocrine hidrocystoma, 2 cases of syringocystadenoma papilliferum, and 1 case of spiradenoma. The 3 specimens of palmar tissue were used as the positive control of eccrine unit, and the 3 specimens of axillary tissue as that of apocrine unit. The results are as follows; HMFG-1 was positive in the cytoplasm and luminal surface of normal apocrine units, and also positive in those of eccrine units. Still more, HMFG-1 was documented as positive even in the eccrine poroma which is originated from eccrine unit. GCDFP-1 was positive in both normal eccrine and apocrine units, and glandular structure was stained stronger than ductal structure. In all of eccrine and apocrine neoplasms, syringoma, eccrine poroma, and spiradenoma which were known to differentiate to ductal structure were negative in GCDFP-15, but hidradenoma, apocrine hidrocystoma, and syringocystadenoma papilliferum which were known to differentiate to glandular structure were positive, partially. All these findings suggest that GCDFP-15 might be a useful marker for glandular differentiation rather than ductal differentiation, and both HMFG-1 and GCDFP-15 might not be useful to discriminate eccrine and apocrine neoplasms. Further intensive studies about normal eccrine and apocrine unit should be performed to determine if HMFG-1 could be used as a significant marker of apocrine unit, and it is necessary to develop new methods for the discrimination of eccrine and apocrine neoplasms.
Acrospiroma ; Cytoplasm ; Discrimination (Psychology) ; Dissent and Disputes ; Hidrocystoma ; Phenobarbital ; Poroma ; Syringoma

No abstract available.
Adenoma, Oxyphilic

Hepatocelluar adenoma is a rare benign tumor, the incidence of which has increased since the introduction of oral contraceptives. We recently experienced a case of hepatocellular adenoma with ovarian Mucinous cystadenoma in a 36 year old female patient who had no history of oral contraceptives usage. The radiologic and pathologic differential diagnosis is discussed in this patient.
Adenoma ; Adenoma, Liver Cell* ; Adult ; Contraceptives, Oral ; Cystadenoma, Mucinous ; Diagnosis, Differential ; Female ; Humans ; Incidence ; Ovary

No abstract available.
Hidrocystoma* ; Syringoma*

BACKGROUND: Different distributions of cytokeratins (CKs) have been found in various layers of the epidermis and in the structure of cutaneous appendages. Benign tumors of the epidermis or cutaneous appendages usually retain the characteristic distribution of CKs of their origin. OBJECTIVE AND METHOD: To elucidate the nature and differentiation of various eccrine gland tumors, we performed immunohistochemical staining using a panel of monoclonal antibodies against CKs in a normal eccrire gland, syringoma, eccrine hidrocystoma, eccrine poroma and clear cell hidradenoma. The tissue distribution of various keratins in the normal eccrine gland was compared with that in varioas eccrine gland tumors. RESULTS: With regard to CKs expression, the results indicated that syringoma represents a tumor differentiating toward both the uppermost part of the dermal duct and the lower intraepidermal duct, and eccrine hidrocystoma represents a tumor differentiating toward the luminal cell of the dermal duct of the eccrine gland. Eccrine poroma cells seemed to be most closed related to the uppermost dermal duct of eccrine gland. We also found that analyse distribution of CKs was insufficient to elucidate the histogenesis of clear cell hidradenoma. CONCLUSION: Analysing CKs is helpful in the analysis of epidermal neoplasms with differentiation toward the eccrine gland.
Acrospiroma ; Antibodies, Monoclonal ; Eccrine Glands* ; Epidermis ; Hidrocystoma ; Keratins* ; Peptides* ; Phenobarbital ; Poroma ; Syringoma ; Tissue Distribution

BACKGROUND: Various eccrine tumors are rather common diseases in clinicians. However, data on the clinicopathologic features of eccrine tumors in Korea are limited. OBJECTIVE: The purpose of this study was to investigate the clinicopathologic characteristics of eccrine tumors in Korea. METHODS: Two hundred and sixty five cases of eccrine tumors, seen from 2002 to 2004 in Korea, were retrospectively analyzed clinically and histopathologically. RESULTS: The most common eccrine tumors identified within Koreans were syringoma (61%), followed by eccrine poroma (13%), eccrine hidrocystoma (9%), and nodular hidradenoma (6%). Moreover, eccrine tumors were usually found to occur in middle-aged woman as multiple asymptomatic skin-colored papules. The most common site of occurrence was the face (45%), followed by the neck (9%), scalp (5%), foot (5%), abdomen (4%), and vulvar (3%). CONCLUSION: The results of this study will be useful and fundamental data on eccrine tumors for clinicians and pathologists.
Abdomen ; Acrospiroma ; Female ; Foot ; Hidrocystoma ; Humans ; Korea ; Neck ; Poroma ; Retrospective Studies ; Scalp ; Syringoma

BACKGROUND: CD44 is the principal cell surface receptor for hyaluronate and exists as multiple isoforms generated by the alternative splicing of up to 10 variant exons. Although certain isofroms may play a role in tumor progression and metastasis formation, the precise function and expression of the variant isoforms are less clear. Since on normal eccrine glands CD44 standard isoform(CD44s) is expressed only in eccrine coil secretory cells, it can be considered as a possible marker of this type of differentiation. However little is known about the expression of CD44 variant isofroms(CD44v) in eccrine gland tumors. OBJECTIVE: The purpose of this study was to investigate the immunohistochemical expression of different CD44 isoforms(CD44s, CD44v4, CD44v6) in the eccrine gland tumors. METHODS: Formalin-fixed and paraffin-embedded tissues from 2 cases of eccrine hidrocystoma, 5 cases of syringoma, 2 cases of eccrine poroma, 2 cases of syringofibroadenoma, 2 cases of nodular hidradenoma were immunolabelled with monoclonal antibody directed CD44s, CD44v4, and CD44v6. RESULTS: Except for syringofibroadenoma, the most tumors cells with eccrine ductal differentiation showed negative staining for CD44s, and positive staining for CD44v4 and CD44v6. Syringofibroadenoma exhibited positive staining for CD44s and CD44v4, but negative staining for CD44v6. Eccrine poroma showed negative staining for CD44s, positive staining for CD44v4, and variable intensity of staining for CD44v6 in different areas of the tumors. In case of nodular hidradenoma, small tubular lumina and clear cells were positive for CD44s. CONCLUSION: Our results suggest that CD44 isoforms can not be a useful marker for an eccrine gland tumor with specific differentiation, but its characteristic pattern of distribution might reflect the variety of functional roles of CD44 isoforms in tumorigenesis of eccrine gland tumors.
Acrospiroma ; Alternative Splicing ; Carcinogenesis ; Eccrine Glands* ; Exons ; Hidrocystoma ; Negative Staining ; Neoplasm Metastasis ; Poroma ; Protein Isoforms* ; Syringoma

OBJECTIVE: Microscopic and endoscopic transsphenoidal approach (TSA) are major surgical techniques in the treatment of pituitary adenoma. Endoscopic endonasal transsphenoidal approach (EETSA) has been increasingly used for pituitary adenomas, however, its surgical outcome particularly in functioning pituitary adenoma has been debated. Here, we investigated the endocrine outcome of the patients with growth hormone (GH) and adrenocorticotropic hormone (ACTH) secreting pituitary adenoma treated by EETSA. METHODS: We treated 80 patients with pituitary adenoma by EETSA since 2004, of which 12 patients were affected by functioning pituitary adenomas (9 GH, 3 ACTH, 0 PRL; 9 macro, 3 micro). Surgical outcome of those patients treated by EETSA was compared with that of the 11 functioning pituitary adenoma patients (8 GH, 3 ACTH; 8 macro, 3 micro) who underwent sublabial microscopic TSA between 1997 and 2003. RESULTS: Imaging remission based on postoperative MRI was achieved in 8 (73%) and hormonal remission in 5 (45%) of 11 patients treated by sublabial microscopic TSA. Imaging remission was observed in 10 (83%, p=0.640) and hormonal remission in 10 (83%, p=0.081) of 12 patients by EETSA. CSF leakage was noticed in 2 (17%) of EETSA group and in 2 (18%) of sublabial microscopic TSA group. Panhypopituitarism was observed in 1 (9%) of EETSA group and in 3 (27%) of sublabial microscopic TSA group. CONCLUSION: EETSA appears to be an effective and safe method for the treatment of functioning pituitary adenomas.
ACTH-Secreting Pituitary Adenoma ; Adrenocorticotropic Hormone ; Endoscopy ; Growth Hormone ; Growth Hormone-Secreting Pituitary Adenoma ; Humans ; Hypopituitarism ; Pituitary Neoplasms

Villous adenomas of the common bile duct are rare and accordingly it is difficult to render a firm preoperative diagnosis. They are the unusual cause of bile duct obstruction and can mimic malignant extrahepatic biliary tumors or stones. Until recently, only a few cases had been reported in the medical literature. Although some authors advocate open surgical excision, especially with recurrence or carcinomatous change, an endoscopic resection of a distal common bile duct adenoma is a viable alternative for those patients considered poor surgical risks. We present two cases of villous adenoma of the common bile duct diagnosed by an endoscopic biopsy and endoscopically resected, with review of the relevant literature on the subject.
Adenoma ; Adenoma, Villous* ; Biopsy ; Cholestasis ; Common Bile Duct* ; Diagnosis* ; Humans ; Recurrence

Nevus sebaceus is a hamartoma that combines epidermal, follicular, sebaceous, and apocrine gland abnormalities. It mostly occurs on the scalp or face and shows characteristically well demarcated yellowish patches or plaque. Clinically several types of cutaneous neoplasms including syringocystadenoma papilliferum, basal cell carcinoma, nodular hidradenoma, syringoma, sebaceous epithelioma, trichilemmoma and apocrine neoplasms have been associated. We herein report a case of nevus sebaceus associated with tubular apocrine adenoma and apocrine poroma of a 11-year-old girl.
Acrospiroma ; Adenoma* ; Apocrine Glands ; Carcinoma ; Carcinoma, Basal Cell ; Child ; Female ; Hamartoma ; Humans ; Nevus* ; Poroma* ; Scalp ; Syringoma