No abstract available.
Gastrointestinal Stromal Tumors*

No abstract available.
Candidiasis* ; Drug Therapy* ; Lymphoma, Non-Hodgkin*

Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the gastrointestinal tract, have represented an important advance in oncology field with the success of molecular targeted therapy. Since the approval of the tyrosine kinase inhibitor (imatinib) in 2002, the survival of patients with advanced GISTs has significantly increased. Accurate histopathologic diagnosis of GISTs and multidisciplinary approach has become more important for successful management of GISTs. Recently, imatinib has become a standard treatment even in adjuvant setting, and regorafenib has been approved for advanced GIST after failure of imatinib and sunitinib. This review presents here the updated results of relevant clinical studies for the further revision to the guideline of Korean GIST study group. We hope this review will help enhance the quality of diagnosis, treatment, and care of patients with GIST in Korea.
Benzamides ; Gastrointestinal Stromal Tumors ; Gastrointestinal Tract ; Humans ; Indoles ; Korea ; Molecular Targeted Therapy ; Phenylurea Compounds ; Piperazines ; Protein-Tyrosine Kinases ; Pyridines ; Pyrimidines ; Pyrroles ; Imatinib Mesylate

No abstract available.
Gastrointestinal Stromal Tumors/*diagnosis ; Humans

BACKGROUND AND OBJECTIVES: Dizziness is the most common symptom of vertebrobasilar insufficiency (VBI), occurring in at least two-thirds of patients. The aim of our study is to document the clinical features and the treatment outcomes in the dizzy patients with VBI. SUBJECTS AND METHOD: A retrospective review of 36 patients suffering dizziness associated with VBI was performed at a tertiary referral center. RESULTS: The most frequent type and duration of dizziness were rotational (52.8%) and minute (55.6%). Sixteen patients (44.4%) reported that their episodes of dizziness occurred several times per a month. Half of the patients had at least one isolated episode of dizziness and in 25% VBI began with an isolated episode of vertigo. Twenty-three patients (63.9%) had risk factors for cerebrovascular diseases. Benign paroxysmal positional vertigo occurred in 27.8%, and 38.9% had a significantly decreased or absent response to caloric stimulation. On the dynamic posturography, visual dysfunction (33.4%) and vestibular dysfunction (19.4%) were observed. Thirty-two patients (88.9%) had abnormal finding on the pure tone audiometry. Nineteen (61.3%) of 31 patients experienced resolution or significant reduction of their episodes of dizziness with treatment. But one patient progressed to acute infarction. CONCLUSION: VBI-associated dizziness cause various clinical manifestations and there should be relevant differential diagnosis for episodic vertigo that last only minutes. We should pay special attention to the VBI in patients with isolated, transient dizziness and the risk factor of the cerebrovascular disease.
Audiometry ; Diagnosis, Differential ; Dizziness ; Humans ; Infarction ; Retrospective Studies ; Risk Factors ; Tertiary Care Centers ; Vertebrobasilar Insufficiency* ; Vertigo

No abstract available.
Diagnosis*

Despite the rarity in incidence and prevalence, gastrointestinal stromal tumor (GIST) has emerged as a distinct pathogenetic entity, and the clinical management of GIST has been evolving very rapidly due to the recent recognition of its oncogenic signal transduction pathway and the introduction of new molecular-targeted therapy. Successful management of GIST in localized and advanced stages requires a multidisciplinary approach firmly based on accurate histopathologic diagnosis. However, standardized guidelines for the management of Korean GIST patients do not exist. This study was performed to provide a guideline for standardized diagnosis and treatment for GIST in Korea. Expert panel members of the Korean GIST Study Group (KGSG) thoroughly reviewed the relevant literature including European Society of Medical Oncology and National Comprehensive Cancer Network guidelines and shared their experience and opinions to make a consensus on twenty-five topics related with pathologic diagnosis, surgical management, and medical treatment of GIST. The consensus described in this article was presented as the basis for a guideline of diagnosis and treatment for patients with GIST that would be used to facilitate the optimal clinical practice in Korea.
Consensus ; Diagnosis ; Gastrointestinal Stromal Tumors ; Humans ; Imatinib Mesylate ; Incidence ; Korea ; Medical Oncology ; Prevalence ; Signal Transduction

No abstract available.
Neurosurgery

No abstract available.
Neurosurgery

No abstract available.
Neurosurgery