PURPOSE: It is agreed that tumor stage is the definitive prognostic indicator for patients with renal cell carcinoma. We investigated pathologic grade and cell subtype as another prognostic in each tumor stage.
Carcinoma, Renal Cell ; Classification ; Diagnosis ; Humans ; Joints ; Medical Records ; Multivariate Analysis ; Neoplasm Staging ; Nephrectomy

No abstract available.
Induction Chemotherapy*

No abstract available.
Induction Chemotherapy*

PURPOSE: Platelet Rich Plasma(PRP) application is increasing with sinus inlay bone graft, but there is few research with radiographic ananlysis on effect of PRP in maxillary sinus. The author investigated the amount of bony changes of maxillary sinus for dental implantation among the patients with maxillary inlay graft. MATERIALS AND METHODS: With 10 patients who were treated with sinus inlay autologous bone grafting combined with PRP technique, and with 5 patients who were treated with sinus inlay grafting only without PRP, the panoramic radiographys which were taken at preoperation, immediate postoperation, 3months postoperation, and 4 months postoperation(a month after dental implantation)periods were analysed. The films had been scanned, and then proceeded throughout image analysis system. The bone density of maxillary grafted sites was compared with adjacent tooth enamel density and remeasured according to density luminosity of each film. The density changes on PRP group and bone graft only group were an lysed with non-parameteric statistics method. RESULTS: In PRP combined patients group, bone density on postoperation periods was increased totally. The remarkable enhanced change of bone density was observed on 3 months postoperation period, thereafter the increasing rate was slightly reduced . In only bone graft patients group, bone density on postoperation periods was also increased compared with preoperation period, but the bone density of 4 months postoperation period was decreased compared with 3 months postoperation period. The amount of bone density on PRP group was significantly changed according to periods in contrast to bone graft only group. CONCLUSION: The bone density on PRP group was remarkably increased at 3 months postoperation compared to bone graft only group and it was seemed to be associated with more new bone formation, less grafted bone resorption at bone grafted sites with PRP.
Blood Platelets* ; Bone Density ; Bone Resorption ; Bone Transplantation ; Dental Enamel ; Dental Implantation ; Dental Implants ; Humans ; Inlays ; Maxillary Sinus ; Osteogenesis ; Platelet-Rich Plasma ; Tooth ; Transplants

BACKGROUND AND AIMS: Mutation of the p53 tumor suppressor gene appears to be an important event in tumor development and progression. Overexpression of the p53 gene product has been widely studied in a variety of neoplasms. METHODS: Immunohistochemical staining was performed on formalin fixed, paraffin embedded histological sections with an anti-human p53 monoclonal antibody (Vector, DO-7) using fifty-two gallbladder carcinomas and thirty two dysplasias. RESULTS: Overexpression of p53 protein was found in 34.6% of invasive carcinomas and 15.6% of dysplasias. Normal epithelium, obtained from all the cases, did not express p53 protein. In addition there was no p53 positive metastatic lymph nodes whose primary tumors were p53 negative. Overexpression of p53 was significantly correlated with lymph node involvement as well as stage of the tumors. Five year survival rate of patients with p53-negative tumors was 46.8%, whereas that of patients with p53-positive tumors was 18.8%. CONCLUSIONS: The progressively increasing incidence of p53 protein overexpression observed from premalignant lesions to invasive tumors supports the view that p53 gene mutations may have a role in the carcinogenesis of gallbladder carcinomas. The fact that p53 protein overexpression was more prevalent in more advanced tumors and in metastatic lymph nodes means that p53 mutation may contribute to the progression of the tumor. Further study is needed to evaluate the significance of p53 as a prognostic factor.
Carcinogenesis ; Epithelium ; Formaldehyde ; Gallbladder* ; Genes, p53 ; Genes, Tumor Suppressor ; Humans ; Incidence ; Lymph Nodes ; Paraffin ; Survival Rate

The extracellular matrix(ECM) is a complex network of different combination of collagens, glycosaminoglycans, laminin, fibronectin, and many other glycoproteins including proteolytic enzymes. The composition and organization of the ECM contributes to the uniques physical or biomechanical properties of a tissue. Fibronectins(FN) are dimeric glycoproteins located on cell surfaces, in the matrix of connective tissue, and in blood. Fibronectins mediate cell attachment to collagen substratum and have been implicated in a variety of important biological processes, including embryogenesis and cell differentiation. The purpose of this study was to determine the effects of surgical induction of anterior disk displacement(ADD) on distribution of fibronectin in the rabbit temporomandibular joint(TMJ) tissues included the articular cartilage, disc, retrodiscal tissue, articular eminence using an immunohistochemical technique. The left TMJ was exposed surgically, and all discal attachments were severed except for the posterior attachment. The disk was then repositioned anteriorly and sutured to the zygomatic arch. The right TMJ served as a sham-operated control. Normal joints were used as a nonoperated control. Fourty-five rabbits were used for experiments in total. For fibronectin immunohistochemical study, eighteen rabbits (one normal group and 5 experimental groups, each group consists of 3 rabbits) were used. The experimental rabbits were sacrified after operation period of 2, 3, 4, 6 and 8 weeks on fibronectin. The obtained results were as follows: 1. Fibronectin immunoreaction on all TMJ tissues(mandibular condyle, articular disc, retrodiscal tissue, articular eminence) in the normal rabbit was observed. Especially the reverse cell layer and proliferation zone of articular cartilage of condyle show strong positive reaction. 2. Depletion of fibronectin in the all TMJ tissues except hypertrophic zone of articular cartilage occurred at 2 weeks following induction of ADD. 3. The restoration of immunoreaction at 4 weeks was observed and a progressive increasing reaction at 6 weeks, 8 weeks also was found. Our study generally showed degenerative changes in TMJ tissues after ADD although TMJ tissues adapted or degenerated to abnormal loads and stress distribution according to the remodeling capacity of TMJ tissues.
Biological Processes ; Cartilage, Articular ; Cell Differentiation ; Collagen ; Connective Tissue ; Embryonic Development ; Extracellular Matrix ; Female ; Fibronectins* ; Glycoproteins ; Glycosaminoglycans ; Joints ; Laminin ; Peptide Hydrolases ; Pregnancy ; Rabbits ; Temporomandibular Joint* ; Zygoma

OBJECTIVE: Behcet? disease (BD) is a chronic inflammatory disorder affecting several organs. The etiology of BD remains unclear, although genetic factors, infectious agents, and immune mechanisms have been studied. The association of BD with certain genetic factors, especially HLA-B51 antigen, is well known in some geographical areas. Nevertheless, the familial occurrence of BD is rare. In this paper, HLA phenotype was evaluated in one family member showing the clustering of BD. METHODS: The serological tissue typing of HLA class I and class II antigens was performed by standard National Institutes of Health microlymphocytotoxicity method in seven family members in which four siblings were affected by BD. The diagnosis of BD was established by the criteria of the International Study Group of BD in these four siblings. RESULTS: In this family study, all members had HLA-A2 and DQ3 antigens. Although HLA-B51 antigen was positive in six out of seven family members, BD was developed in three of the six having HLA-B51 antigen. Three siblings had the exact same HLA phenotype. However, only one person had BD among three siblings with identical HLA phenotype. In addition, all siblings who developed erythema nodosum-like lesion had HLA-B51 antigen. CONCLUSION: This family suggests that the familial clustering of BD may not be explained solely by a susceptible HLA phenotype. The environmental factor or other genetic factors besides HLA-B51 might play a role in the development of BD. Furthermore, more studies and information will be needed to clarify the role of A2 and DQ3 antigens in BD.
Diagnosis ; Erythema ; Histocompatibility Antigens Class II ; Histocompatibility Testing ; HLA Antigens* ; HLA-A2 Antigen ; HLA-B51 Antigen ; Humans ; National Institutes of Health (U.S.) ; Phenotype ; Siblings

The synovial membrane of the temporomandibular joint lines all the intraarticular structures except the articular cartilage of the articular eminence, fossa, the mandibular condyle and the articular disc. The synovial membrane consists of two layers. The first layer is a lining cell layer facing the joint space and called synovial intima. The second layer is called subintimal or subsynovial tissue. The synovial membrane fulfills several important functions in maintaining normal joint physiology and joint function. Synovitis occurs when the level of cellular debris and the concentration of chemical mediators of inflammation produce levels that the synovial membrane is unable to ingest, absorb or process. So degeneration of temporomandibular joint may be increased by deficiency of synovial fluid. After general anesthesia by intramuscular injection of ketamin, exposure of TMJ of rabbit was done by preauricular approach. After exposure, rubber drain was inserted into the upper joint cavity, to prevent accumulation of synovial fluid. Penicillin G was used to prevent secondary infection for 3 days. Fifteen Rabbits were used for experiment, and subdivided into 5 groups (one normal group and 4 experimental groups, each subdivided group consisted in 3 rabbits). Experimental groups were taken after period of 1, 2, 3, 4 weeks. After euthansia, enbloc excision of TMJ was done to make biopsy specimen. The results were as follows; 1. Layers of synovial intima were increased in experimental group, 8~10 layers in first week group and 4~5 layers in fourth week group as compared with 2~3 layers in normal group. 2. Inflammation, vascular change and subintimal edema were highest in second week group, but continued to fourth week group. 3. Subintimal fibrosis occured in second week group, and increased to fourth week group. 4. Due to fibrosis of joint cavity, narrowing of joint space occured in the third week group, and increased to fourth week group. 5. Degeneration of articular disc occured in second week group and increased to fourth week group.
Anesthesia, General ; Biopsy ; Cartilage, Articular ; Coinfection ; Edema ; Fibrosis ; Inflammation ; Inflammation Mediators ; Injections, Intramuscular ; Joints* ; Mandibular Condyle ; Penicillin G ; Physiology ; Rabbits* ; Rubber ; Synovial Fluid* ; Synovial Membrane ; Synovitis ; Temporomandibular Joint

OBJECTIVE: Behcet? disease (BD) is a chronic inflammatory disorder affecting several organs. The etiology of BD remains unclear, although genetic factors, infectious agents, and immune mechanisms have been studied. The association of BD with certain genetic factors, especially HLA-B51 antigen, is well known in some geographical areas. Nevertheless, the familial occurrence of BD is rare. In this paper, HLA phenotype was evaluated in one family member showing the clustering of BD. METHODS: The serological tissue typing of HLA class I and class II antigens was performed by standard National Institutes of Health microlymphocytotoxicity method in seven family members in which four siblings were affected by BD. The diagnosis of BD was established by the criteria of the International Study Group of BD in these four siblings. RESULTS: In this family study, all members had HLA-A2 and DQ3 antigens. Although HLA-B51 antigen was positive in six out of seven family members, BD was developed in three of the six having HLA-B51 antigen. Three siblings had the exact same HLA phenotype. However, only one person had BD among three siblings with identical HLA phenotype. In addition, all siblings who developed erythema nodosum-like lesion had HLA-B51 antigen. CONCLUSION: This family suggests that the familial clustering of BD may not be explained solely by a susceptible HLA phenotype. The environmental factor or other genetic factors besides HLA-B51 might play a role in the development of BD. Furthermore, more studies and information will be needed to clarify the role of A2 and DQ3 antigens in BD.
Diagnosis ; Erythema ; Histocompatibility Antigens Class II ; Histocompatibility Testing ; HLA Antigens* ; HLA-A2 Antigen ; HLA-B51 Antigen ; Humans ; National Institutes of Health (U.S.) ; Phenotype ; Siblings

Uterine torsion is defined as the mtation of more than 45 degrees around the long axis of the uterus or a rotation which is severe enough to produce symptoms. Torsion of the human pregnant uterus is a very rare complication. The diagnosis is problematic and is often made during a cesrean section due to inhibited labor. Torsion of the human pregnant uterus can be caused by myoma or other uterine abnormalities, ovarian cysts, adhesions, abnormal fetal presentations, or fetal abnormalities ( though no cause can be found in about 20% of cases ). Uterine torsion produces symptoms of varying severity depending on the degree of rotation, and duration of the pregnancy. High mortality rates for both mother and infant have been reported. We experienced one case of the torsion of term pregnant uterus and report this case with a brief review of the concerned literature.
Axis, Cervical Vertebra ; Diagnosis ; Female ; Fetus* ; Humans ; Infant ; Mortality ; Mothers ; Myoma ; Ovarian Cysts ; Pregnancy ; Uterus*