Isoimmune hemolytic disease of the newborn due to anti-E is a disease characterized by the progressive neonatal hyperbilimbinemia and anemia which is caused by the IgG antibody transmitted from the mother to the ferns. Authors have experienced two cases of isoimmune hemolytic disease due to anti-E, who presented with jaundice on the first and the second day of life, respectively. The ABO and Rh blood types of their mother and father were B, CcDee and O, ccDEE, respectively. Both babies showed positive direct Coombs test and the mother showed strong positive indirect Coombs test. Antibody identification tests were made only in the first case and the mother, both of which revealed anti-E antibody. The first case was treated with phototherapy for 3 days and two blood transfusions. The second case was treated with phototherapy for 6 days and two exchange transfusions.
Anemia ; Blood Transfusion ; Coombs Test ; Fathers ; Ferns ; Humans ; Immunoglobulin G ; Infant, Newborn ; Jaundice ; Mothers ; Phototherapy ; Siblings*

Median raphe canal is an uncommon disease and represents a defect abnormality of the male genitalia. It occurs along the ventral median raphe from the glans penis to the anus. Histologically the canal is lined by stratified squamous epithelium which dose not communicate with the urethra. Surgical excision is the treatment of choice. Recently we observed a 25-year-old male patient who had had a median raphe canal located in the ventral aspect of penis.
Adult ; Anal Canal ; Epithelium ; Genitalia, Male ; Humans ; Male ; Penis* ; Urethra

The lymphoepitheliomalike carcinoma of the cervix is histologically similar to lymphoepithelioma of the nasopharyngeal region or medullary carcinoma of the breast which has grossly circumscribed, histologically poorly differentiated nonkeratinized squamous cell carcinoma with prominent stromal inflammation. Although the entity has been rarely reported in the united states, it has been reported relatively common in Japan. The Japanese literature suggests that patient with this varient may have a more favorable prognosis when compared with the usual squamous cell carcinoma of the cervix A patient with a squamous cell carcinoma of the uterine cervix with marked lymphocyte and plasma cell infiltration is reported and the literature reviewed.
Asian Continental Ancestry Group ; Breast ; Carcinoma, Medullary ; Carcinoma, Squamous Cell ; Cervix Uteri* ; Female ; Humans ; Inflammation ; Japan ; Lymphocytes ; Plasma Cells ; Prognosis ; United States ; Uterine Cervical Neoplasms

Median raphe canal is an uncommon disease and represents a defect abnormality of the male genitalia. It occurs along the ventral median raphe from the glans penis to the anus. Histologically the canal is lined by stratified squamous epithelium which dose not communicate with the urethra. Surgical excision is the treatment of choice. Recently we observed a 25-year-old male patient who had had a median raphe canal located in the ventral aspect of penis.
Adult ; Anal Canal ; Epithelium ; Genitalia, Male ; Humans ; Male ; Penis* ; Urethra

The lymphoepitheliomalike carcinoma of the cervix is histologically similar to lymphoepithelioma of the nasopharyngeal region or medullary carcinoma of the breast which has grossly circumscribed, histologically poorly differentiated nonkeratinized squamous cell carcinoma with prominent stromal inflammation. Although the entity has been rarely reported in the united states, it has been reported relatively common in Japan. The Japanese literature suggests that patient with this varient may have a more favorable prognosis when compared with the usual squamous cell carcinoma of the cervix A patient with a squamous cell carcinoma of the uterine cervix with marked lymphocyte and plasma cell infiltration is reported and the literature reviewed.
Asian Continental Ancestry Group ; Breast ; Carcinoma, Medullary ; Carcinoma, Squamous Cell ; Cervix Uteri* ; Female ; Humans ; Inflammation ; Japan ; Lymphocytes ; Plasma Cells ; Prognosis ; United States ; Uterine Cervical Neoplasms

The aim of this study was to analyze the effect of age at beginning of treatment on the results of anisometropic amblyopia in twenty-two consecutive children. The children who had strabismus or any other ocular disease affecting visual acuity was excluded. Two age groups were defined, according to the age at which treatment was started : 7 years or less(group I. N=10), 8 years or more(group II. N=12). Mean age of group I was 5.3 years old(4.1-7.9), while group II was 10.2 years old(8.0-13.2). Six patients were treated with occlusion therapy, 11 patients with atropine penalization, 1 patient with occlusion therapy and atropine penalization alternatively and 4 patients with spectacle correction only. All children had cycloplegic refraction before treatment and at each visit the corrected visual acuity was assessed. The difference in refractive errors between two eyes before treatment was 2.58D(1-9D) in group I and 2.75D in group II. The mean initial corrected visual acuity of amblyopic eyes was 0.43 in group I and 0.46 in group II. There was no significant difference in initial visual acuity between the two groups. The range of follow up times was from 5 to 60 months, with an average of 18 months. There was no significant difference in final visual outcome of amblyopic eye between the two groups. For patients aged 7 years or less, 80%(8/10) of patients achieved a final visual acuity of 0.8 or better and 90%(9/10) achieved the same final visual acuity as in the sound eye. For patients aged 8 years or more, 83%(11/12) of patients achieved a final visual acuity of 0.8 or better and 83%(10/12) achieved the same final visual acuity as in the sound eye. The initial visual acuity, the methods of therapy did not affect the final visual outcome. In pure anisometropic amblyopia, the patients older than 8 years of age have been treated as effectively as the patients 7 years or less.
Age Factors ; Amblyopia ; Anisometropia ; Atropine ; Child ; Follow-Up Studies ; Humans ; Refractive Errors ; Strabismus ; Treatment Outcome ; Visual Acuity

The aim of this study was to analyze the effect of age at beginning of treatment on the results of anisometropic amblyopia in twenty-two consecutive children. The children who had strabismus or any other ocular disease affecting visual acuity was excluded. Two age groups were defined, according to the age at which treatment was started : 7 years or less(group I. N=10), 8 years or more(group II. N=12). Mean age of group I was 5.3 years old(4.1-7.9), while group II was 10.2 years old(8.0-13.2). Six patients were treated with occlusion therapy, 11 patients with atropine penalization, 1 patient with occlusion therapy and atropine penalization alternatively and 4 patients with spectacle correction only. All children had cycloplegic refraction before treatment and at each visit the corrected visual acuity was assessed. The difference in refractive errors between two eyes before treatment was 2.58D(1-9D) in group I and 2.75D in group II. The mean initial corrected visual acuity of amblyopic eyes was 0.43 in group I and 0.46 in group II. There was no significant difference in initial visual acuity between the two groups. The range of follow up times was from 5 to 60 months, with an average of 18 months. There was no significant difference in final visual outcome of amblyopic eye between the two groups. For patients aged 7 years or less, 80%(8/10) of patients achieved a final visual acuity of 0.8 or better and 90%(9/10) achieved the same final visual acuity as in the sound eye. For patients aged 8 years or more, 83%(11/12) of patients achieved a final visual acuity of 0.8 or better and 83%(10/12) achieved the same final visual acuity as in the sound eye. The initial visual acuity, the methods of therapy did not affect the final visual outcome. In pure anisometropic amblyopia, the patients older than 8 years of age have been treated as effectively as the patients 7 years or less.
Age Factors ; Amblyopia ; Anisometropia ; Atropine ; Child ; Follow-Up Studies ; Humans ; Refractive Errors ; Strabismus ; Treatment Outcome ; Visual Acuity

The aim of this study was to analyze the effect of age at beginning of treatment on the results of anisometropic amblyopia in twenty-two consecutive children. The children who had strabismus or any other ocular disease affecting visual acuity was excluded. Two age groups were defined, according to the age at which treatment was started : 7 years or less(group I. N=10), 8 years or more(group II. N=12). Mean age of group I was 5.3 years old(4.1-7.9), while group II was 10.2 years old(8.0-13.2). Six patients were treated with occlusion therapy, 11 patients with atropine penalization, 1 patient with occlusion therapy and atropine penalization alternatively and 4 patients with spectacle correction only. All children had cycloplegic refraction before treatment and at each visit the corrected visual acuity was assessed. The difference in refractive errors between two eyes before treatment was 2.58D(1-9D) in group I and 2.75D in group II. The mean initial corrected visual acuity of amblyopic eyes was 0.43 in group I and 0.46 in group II. There was no significant difference in initial visual acuity between the two groups. The range of follow up times was from 5 to 60 months, with an average of 18 months. There was no significant difference in final visual outcome of amblyopic eye between the two groups. For patients aged 7 years or less, 80%(8/10) of patients achieved a final visual acuity of 0.8 or better and 90%(9/10) achieved the same final visual acuity as in the sound eye. For patients aged 8 years or more, 83%(11/12) of patients achieved a final visual acuity of 0.8 or better and 83%(10/12) achieved the same final visual acuity as in the sound eye. The initial visual acuity, the methods of therapy did not affect the final visual outcome. In pure anisometropic amblyopia, the patients older than 8 years of age have been treated as effectively as the patients 7 years or less.
Age Factors ; Amblyopia ; Anisometropia ; Atropine ; Child ; Follow-Up Studies ; Humans ; Refractive Errors ; Strabismus ; Treatment Outcome ; Visual Acuity

The aim of this study was to analyze the effect of age at beginning of treatment on the results of anisometropic amblyopia in twenty-two consecutive children. The children who had strabismus or any other ocular disease affecting visual acuity was excluded. Two age groups were defined, according to the age at which treatment was started : 7 years or less(group I. N=10), 8 years or more(group II. N=12). Mean age of group I was 5.3 years old(4.1-7.9), while group II was 10.2 years old(8.0-13.2). Six patients were treated with occlusion therapy, 11 patients with atropine penalization, 1 patient with occlusion therapy and atropine penalization alternatively and 4 patients with spectacle correction only. All children had cycloplegic refraction before treatment and at each visit the corrected visual acuity was assessed. The difference in refractive errors between two eyes before treatment was 2.58D(1-9D) in group I and 2.75D in group II. The mean initial corrected visual acuity of amblyopic eyes was 0.43 in group I and 0.46 in group II. There was no significant difference in initial visual acuity between the two groups. The range of follow up times was from 5 to 60 months, with an average of 18 months. There was no significant difference in final visual outcome of amblyopic eye between the two groups. For patients aged 7 years or less, 80%(8/10) of patients achieved a final visual acuity of 0.8 or better and 90%(9/10) achieved the same final visual acuity as in the sound eye. For patients aged 8 years or more, 83%(11/12) of patients achieved a final visual acuity of 0.8 or better and 83%(10/12) achieved the same final visual acuity as in the sound eye. The initial visual acuity, the methods of therapy did not affect the final visual outcome. In pure anisometropic amblyopia, the patients older than 8 years of age have been treated as effectively as the patients 7 years or less.
Age Factors ; Amblyopia ; Anisometropia ; Atropine ; Child ; Follow-Up Studies ; Humans ; Refractive Errors ; Strabismus ; Treatment Outcome ; Visual Acuity

The aim of this study was to analyze the effect of age at beginning of treatment on the results of anisometropic amblyopia in twenty-two consecutive children. The children who had strabismus or any other ocular disease affecting visual acuity was excluded. Two age groups were defined, according to the age at which treatment was started : 7 years or less(group I. N=10), 8 years or more(group II. N=12). Mean age of group I was 5.3 years old(4.1-7.9), while group II was 10.2 years old(8.0-13.2). Six patients were treated with occlusion therapy, 11 patients with atropine penalization, 1 patient with occlusion therapy and atropine penalization alternatively and 4 patients with spectacle correction only. All children had cycloplegic refraction before treatment and at each visit the corrected visual acuity was assessed. The difference in refractive errors between two eyes before treatment was 2.58D(1-9D) in group I and 2.75D in group II. The mean initial corrected visual acuity of amblyopic eyes was 0.43 in group I and 0.46 in group II. There was no significant difference in initial visual acuity between the two groups. The range of follow up times was from 5 to 60 months, with an average of 18 months. There was no significant difference in final visual outcome of amblyopic eye between the two groups. For patients aged 7 years or less, 80%(8/10) of patients achieved a final visual acuity of 0.8 or better and 90%(9/10) achieved the same final visual acuity as in the sound eye. For patients aged 8 years or more, 83%(11/12) of patients achieved a final visual acuity of 0.8 or better and 83%(10/12) achieved the same final visual acuity as in the sound eye. The initial visual acuity, the methods of therapy did not affect the final visual outcome. In pure anisometropic amblyopia, the patients older than 8 years of age have been treated as effectively as the patients 7 years or less.
Age Factors ; Amblyopia ; Anisometropia ; Atropine ; Child ; Follow-Up Studies ; Humans ; Refractive Errors ; Strabismus ; Treatment Outcome ; Visual Acuity