No abstract available.
Humans ; Male

No abstract available.
Animals ; Basement Membrane* ; Rats*

PURPOSE: We analyzed climacteric symptoms, bone mineral density (BMD), serum estradiol (E2) and follicle stimulating hormone (FSH) to identify the health benefits of meridian massage in perimenopausal women. METHODS: There were 16 women in the experimental group and 17 people in the control group. Meridian massage was performed for 4 weeks, 3 times a week for 20 minutes each session. The data were collected pre-treatment, posttreatment and 4 weeks after treatment. SPSS/WIN 11.5 was used for data analysis. RESULTS: After meridian massage, there were significant differences in climacteric symptoms (U = 65.50, p = .011) and BMD (U = 65.50, p = .011) between the two groups. The E2 level showed a significant difference between the two groups pre- and posttreatment (U = 75.00, p = .028). FSH showed a significant increase when measured at 4 weeks after the treatment as compared with the amount when measured post-treatment within the control group (z = -2.249, p = .025), experimental group showed a stable change in FSH. but there was no significant difference between the groups. CONCLUSION: In this study, we confirmed the effects of Meridian massage in decreasing climacteric symptoms, inhibiting the decrease of BMD and stabilizing serum hormone in perimenopausal women. Therefore, it can be considered for use as a nursing intervention for health management in perimenopausal women.
Bone Density ; Climacteric ; Estradiol ; Female ; Follicle Stimulating Hormone ; Humans ; Insurance Benefits ; Massage ; Statistics as Topic

PURPOSE: This study was to investigate the relation among social support, drinking and smoking and to identify factors affecting high school students' smoking and drinking behaviors. METHODS: Data were collected from 361 high school students (182 students in 2 preparatory schools and 179 students in 2 vocational high schools) who were selected through convenient sampling. Data were analyzed using SPSS 11.5 for Windows. RESULTS: Factors affecting smoking behavior were drinking(OR=15.86. p<0.01), school type(R=11.82, p<0.01), school record(OR=46.62. p<0.001), pocket money (OR= 10.91. p<0.01) and brother's smoking (OR=9.09. p<0.05). Factors affecting drinking behavior were smoking(OR=8.32. p<0.01), school type(OR=2.53. p<0.01), school record(OR=2.35. p<0.01), pocket money(OR=2.01. p<0.05), father's educational background(OR=2.126. p<0.05), mother's drinking(OR= 1.83. p<0.05) and relationship with teacher (OR=2.44. p<0.01). CONCLUSION: The behaviors of drinking and smoking in high school students were highly correlated with each other. School record, school type, pocket money and family member's behaviors influenced student's behaviors. Further study is required to estimate the effect of drinking and smoking intervention programs according to student's characteristics such as school record, school type, pocket money management, and family members' influence.
Drinking Behavior ; Drinking ; Humans ; Smoke ; Smoking

PURPOSE: This study was to investigate the relation among social support, drinking and smoking and to identify factors affecting high school students' smoking and drinking behaviors. METHODS: Data were collected from 361 high school students (182 students in 2 preparatory schools and 179 students in 2 vocational high schools) who were selected through convenient sampling. Data were analyzed using SPSS 11.5 for Windows. RESULTS: Factors affecting smoking behavior were drinking(OR=15.86. p<0.01), school type(R=11.82, p<0.01), school record(OR=46.62. p<0.001), pocket money (OR= 10.91. p<0.01) and brother's smoking (OR=9.09. p<0.05). Factors affecting drinking behavior were smoking(OR=8.32. p<0.01), school type(OR=2.53. p<0.01), school record(OR=2.35. p<0.01), pocket money(OR=2.01. p<0.05), father's educational background(OR=2.126. p<0.05), mother's drinking(OR= 1.83. p<0.05) and relationship with teacher (OR=2.44. p<0.01). CONCLUSION: The behaviors of drinking and smoking in high school students were highly correlated with each other. School record, school type, pocket money and family member's behaviors influenced student's behaviors. Further study is required to estimate the effect of drinking and smoking intervention programs according to student's characteristics such as school record, school type, pocket money management, and family members' influence.
Drinking Behavior ; Drinking ; Humans ; Smoke ; Smoking

PURPOSE: This study was to investigate the relation among social support, drinking and smoking and to identify factors affecting high school students' smoking and drinking behaviors. METHODS: Data were collected from 361 high school students (182 students in 2 preparatory schools and 179 students in 2 vocational high schools) who were selected through convenient sampling. Data were analyzed using SPSS 11.5 for Windows. RESULTS: Factors affecting smoking behavior were drinking(OR=15.86. p<0.01), school type(R=11.82, p<0.01), school record(OR=46.62. p<0.001), pocket money (OR= 10.91. p<0.01) and brother's smoking (OR=9.09. p<0.05). Factors affecting drinking behavior were smoking(OR=8.32. p<0.01), school type(OR=2.53. p<0.01), school record(OR=2.35. p<0.01), pocket money(OR=2.01. p<0.05), father's educational background(OR=2.126. p<0.05), mother's drinking(OR= 1.83. p<0.05) and relationship with teacher (OR=2.44. p<0.01). CONCLUSION: The behaviors of drinking and smoking in high school students were highly correlated with each other. School record, school type, pocket money and family member's behaviors influenced student's behaviors. Further study is required to estimate the effect of drinking and smoking intervention programs according to student's characteristics such as school record, school type, pocket money management, and family members' influence.
Drinking Behavior ; Drinking ; Humans ; Smoke ; Smoking

For the study on the effect of retinoic acid on the formation of palatal rugae and the cleft palate, retinoic acid was administered orally 150mg/kg of body weight by gastric tube at GD 10.5 to Sprague-Dawley rats. The pregnant rats were sacrificed on GD 17.5 under ether anesthesia, and laparatomized. After removal of uterus, the number of pregnant sacs and fetuses were counted. The fetuses weighed, the MEE (medial edge epithelium) thickness measured and the mitotic figures counted after routine processing and H·E stain. All the palates were photographed, and the number of rugae & the rugal pattern analysed. TEM photographs of MEE cells were observed after routine processing. The results were as follows ; 1. Rat fetus body weight after retinoic acid treatment increased significantly compared with the control group. 2. Mitotic figures in the retinoic acid treated group increased significantly compared with control group. 3. In the retinoic acid treated group, 79.3% of fetuses had cleft palates. Among fetuses with cleft palates, complete cleft palates were 10.6%, incomplete cleft palate 89.4%. Incomplete clefts were of two types ; median type (cleft palate at the intermolar region) and soft palate type (cleft posterior to the 8th rugae). Median type was 64.6% and the soft palate type 35.4%. 4. 2.3% of the fetuses had the numerical anomaly of the palatal rugae in the control group, but that of retinoic acid treated group 87.7%. 5. 17.4% of palatal rugae of the control group was disrupted, but 100% of the retinoic acid treated group disrupted. 6. Rugal papillae were observed in the 15.1% of fetuses of the control group and 63.1% of fetuses of the retinoic acid treated group. 7. Longitudinal rugae were observed in 19% of fetuses of the retinoic acid treated group, but not in the control group. 8. In TEM photographs, cytoplasmic processes, intercellular space, and desmosomes decreased. Swelling of mitochondria & ER were also found in the retinoic acid treated groups. According to the above results, it appears that there is close relationship between palatal rugae and cleft palates, and that excess retinoic acid induces disruption of pattern and numerical variations of rat fetus palate rugae. Also retinoic acid has an inhibitory effect on the proliferation of medial edge epithelial cells of palatal shelves. The cleft palates may be induced by the above mentioned retinoic acid effects. But, the exact mechanisms of retinoic acid on cleft palate formation is not thoroughly known and should be further studied.
Anesthesia ; Animals ; Body Weight ; Cleft Palate* ; Cytoplasm ; Desmosomes ; Epithelial Cells ; Ether ; Extracellular Space ; Fetus ; Mitochondria ; Palate ; Palate, Soft ; Rats ; Rats, Sprague-Dawley ; Tretinoin* ; Uterus

For the study on the effect of retinoic acid on the formation of palatal rugae and the cleft palate, retinoic acid was administered orally 150mg/kg of body weight by gastric tube at GD 10.5 to Sprague-Dawley rats. The pregnant rats were sacrificed on GD 17.5 under ether anesthesia, and laparatomized. After removal of uterus, the number of pregnant sacs and fetuses were counted. The fetuses weighed, the MEE (medial edge epithelium) thickness measured and the mitotic figures counted after routine processing and H·E stain. All the palates were photographed, and the number of rugae & the rugal pattern analysed. TEM photographs of MEE cells were observed after routine processing. The results were as follows ; 1. Rat fetus body weight after retinoic acid treatment increased significantly compared with the control group. 2. Mitotic figures in the retinoic acid treated group increased significantly compared with control group. 3. In the retinoic acid treated group, 79.3% of fetuses had cleft palates. Among fetuses with cleft palates, complete cleft palates were 10.6%, incomplete cleft palate 89.4%. Incomplete clefts were of two types ; median type (cleft palate at the intermolar region) and soft palate type (cleft posterior to the 8th rugae). Median type was 64.6% and the soft palate type 35.4%. 4. 2.3% of the fetuses had the numerical anomaly of the palatal rugae in the control group, but that of retinoic acid treated group 87.7%. 5. 17.4% of palatal rugae of the control group was disrupted, but 100% of the retinoic acid treated group disrupted. 6. Rugal papillae were observed in the 15.1% of fetuses of the control group and 63.1% of fetuses of the retinoic acid treated group. 7. Longitudinal rugae were observed in 19% of fetuses of the retinoic acid treated group, but not in the control group. 8. In TEM photographs, cytoplasmic processes, intercellular space, and desmosomes decreased. Swelling of mitochondria & ER were also found in the retinoic acid treated groups. According to the above results, it appears that there is close relationship between palatal rugae and cleft palates, and that excess retinoic acid induces disruption of pattern and numerical variations of rat fetus palate rugae. Also retinoic acid has an inhibitory effect on the proliferation of medial edge epithelial cells of palatal shelves. The cleft palates may be induced by the above mentioned retinoic acid effects. But, the exact mechanisms of retinoic acid on cleft palate formation is not thoroughly known and should be further studied.
Anesthesia ; Animals ; Body Weight ; Cleft Palate* ; Cytoplasm ; Desmosomes ; Epithelial Cells ; Ether ; Extracellular Space ; Fetus ; Mitochondria ; Palate ; Palate, Soft ; Rats ; Rats, Sprague-Dawley ; Tretinoin* ; Uterus

No abstract available.
Fixatives* ; Mast Cells*

An aphidicolin is a chemical agent which selectively inhibits DNA polymerase alpha in S phase of cell cycle. The purpose of this study is toinvestigate of chromosomal abnormalities including fragile sites induced by 0.2 microgram/ml and 0.4 ng/ml aphidicolin in lymphocyte cultures of six healthy individuals. The results were follows. 1. A significant decreasing in mitotic indexes in respect to control culture was observed with both aphidicolin concentrations used. 2. The cells showing chromosome aberrations and the total number of cytogeneticic alterations were significantly increased both aphidicolin treated cultures than control cultures. 3. The total numbers of chromosomal aberrations were increased in the concentration of 0.4 microgram/ml aphidicolin compared to 0.2 microgram/ml treated groups. 4. The most frequent type of chromosomal aberration is a gap. 5. A site showing a gap or break was defined as common fragile sites (c-fra) if it appeared more than 1% of cells analyzed and in at least three of six individuals studied with the same culture treatment. Using these criteria, 3p14, 4q12, 5p13, 6q16, 9p13, and 16q23 were induced in different proportions by different concentration of aphidicolin and four of these c-fras, 4q12, 5p13, 6q16, 9p13 have not been reported so far. This results support that aphidicolin induced fragile sites differently according to cultured cell or cultured conditions, and also suggest the mechanism that common fragile sites caused be closely related with the defect of DNA synthesis in the S phase of cell cycle.
Aphidicolin* ; Cell Cycle ; Cells, Cultured ; Chromosome Aberrations ; Cytogenetics ; DNA ; DNA Polymerase I ; Humans* ; Lymphocytes* ; Mitotic Index ; S Phase