1.Translocation of p53 Protein in Melanocytes and Malignant Melanoma Cells After UVB Irradiation.
Kyoung Hee CHOI ; Hye Jin KIM ; Yong CHOI ; Kyu Han KIM ; Kyoung Chan PARK
Annals of Dermatology 2001;13(3):133-138
BACKGROUND: UVB is responsible for most of the carcinogenic effects of sun exposure. OBJECTIVE: Aim of this study was to investigate the regulation and intracellular redistribution of p53 protein after UVB irradiation. METHODS: Cultured normal human melanocytes and G361 melanoma cells were used for west-ern blotting and confocal microscopic examination for determining expression and distribution of p53. RESULTS: UVB irradiation increased p53 expression in cultured normal human melanocytes and G361 malignant melanoma cells according to increasing doses of UVB. Furthermore, p53 moved from cytosol to nucleus after UVB irradiation. CONCLUSIONS: UVB irradiation induced overexpression and redistribution of p53 in cultured normal human melanocytes and G361 malignant melanoma cells.
Cytosol
;
Humans
;
Melanocytes*
;
Melanoma*
;
Solar System
2.Clinical Evaluation of Minor Clinical Features of Atopic Dermatitis
Kyu Han KIM ; Jin Ho CHUNG ; Kyoung Chan PARK
Annals of Dermatology 1993;5(1):9-12
BACKGROUND: Recently doubts have been raised regarding the diagnostic significance of some of the minor clinical features of atopic dermatitis (AD) proposed by Hanifin and Rajka. Some of them may be nonspecific and racial difference was suggested. OBJECTIVE: The purpose of this study is to evaluate the diagnostic significance of 14 minor clinical features out of Hanifin and Rajka's 23 minor features of AD in the Korean pediatric population. The significance of 5 more items was evaluated as additional minor features. METHODS: The difference in frequency of the total 19 features of AD was compared between 100 patients with AD and 76 controls. RESULTS: Fourteen of these were shown to be significantly more frequent in patients than in controls including our 5 additional clues such as scalp scaling, postauricular fissure, infraauricular fissure, forehead lichenification, and infragluteal eczema. CONCLUSION: Our study about the minor features may be a valuable guideline for the diagnosis of AD in the Korean pediatric population.
Dermatitis, Atopic
;
Diagnosis
;
Eczema
;
Forehead
;
Humans
;
Scalp
3.Treatment of Neovaseular Glaucoma Using Modified Schocket Implant
Journal of the Korean Ophthalmological Society 1993;34(12):1293-1299
Seven eyes of 7 patients had undergone modified Schocketimplant surgery for neovascular glaucoma. The mean preoperative intraocular pressure(IOP) was 49.1 +/- 10.1 mmHg(range 38 to 70 mmHg). With a follow up of 6 to 18 monnths, the mean postoperative IOP was 20.3+/-5.1 mmHg(range 16 to 30 mmHg). The author's personal method to make two oblique valve incisions on the obliterated distal end of the draining silicone tube, prevented early postoperative complications(flat anterior chamber and hypo-tony). The one oblique incision on silicone tube turned into a open valve at a pressure between 17.3 and 21.6 mmHg(average 19.3 mmHg) and two oblique incisions opened at a oblique incisions seemed to be more available for pressure sensitive valve. The complications included minimal hyphema(4 eyes) and progression of cataract(1 eye). Modified Schocket implant are an effective and simple technique in the management of neovascular glaucoma.
Anterior Chamber
;
Follow-Up Studies
;
Glaucoma
;
Glaucoma, Neovascular
;
Humans
;
Intraocular Pressure
;
Silicones
4.Treatment of Neovaseular Glaucoma Using Modified Schocket Implant
Journal of the Korean Ophthalmological Society 1993;34(12):1293-1299
Seven eyes of 7 patients had undergone modified Schocketimplant surgery for neovascular glaucoma. The mean preoperative intraocular pressure(IOP) was 49.1 +/- 10.1 mmHg(range 38 to 70 mmHg). With a follow up of 6 to 18 monnths, the mean postoperative IOP was 20.3+/-5.1 mmHg(range 16 to 30 mmHg). The author's personal method to make two oblique valve incisions on the obliterated distal end of the draining silicone tube, prevented early postoperative complications(flat anterior chamber and hypo-tony). The one oblique incision on silicone tube turned into a open valve at a pressure between 17.3 and 21.6 mmHg(average 19.3 mmHg) and two oblique incisions opened at a oblique incisions seemed to be more available for pressure sensitive valve. The complications included minimal hyphema(4 eyes) and progression of cataract(1 eye). Modified Schocket implant are an effective and simple technique in the management of neovascular glaucoma.
Anterior Chamber
;
Follow-Up Studies
;
Glaucoma
;
Glaucoma, Neovascular
;
Humans
;
Intraocular Pressure
;
Silicones
5.Treatment of Neovaseular Glaucoma Using Modified Schocket Implant
Journal of the Korean Ophthalmological Society 1993;34(12):1293-1299
Seven eyes of 7 patients had undergone modified Schocketimplant surgery for neovascular glaucoma. The mean preoperative intraocular pressure(IOP) was 49.1 +/- 10.1 mmHg(range 38 to 70 mmHg). With a follow up of 6 to 18 monnths, the mean postoperative IOP was 20.3+/-5.1 mmHg(range 16 to 30 mmHg). The author's personal method to make two oblique valve incisions on the obliterated distal end of the draining silicone tube, prevented early postoperative complications(flat anterior chamber and hypo-tony). The one oblique incision on silicone tube turned into a open valve at a pressure between 17.3 and 21.6 mmHg(average 19.3 mmHg) and two oblique incisions opened at a oblique incisions seemed to be more available for pressure sensitive valve. The complications included minimal hyphema(4 eyes) and progression of cataract(1 eye). Modified Schocket implant are an effective and simple technique in the management of neovascular glaucoma.
Anterior Chamber
;
Follow-Up Studies
;
Glaucoma
;
Glaucoma, Neovascular
;
Humans
;
Intraocular Pressure
;
Silicones
6.The Effect of Long-term Steroed Therapy combined with Azathioprine in Henoch-Schonlein Nephritis
Kyoung Sang MOON ; So Young JIN ; Eun Mi KIM
Journal of the Korean Society of Pediatric Nephrology 1998;2(2):118-124
We describe cytologic findings of two cases of pilomatrixoma which had been cytologically misdiagnosed as suspicious malignant and malignant lesions in 35 year-old and 22 year-old females who presented a palpable neck mass. The cytologic smears showed many basaloid cells with a high nuclear-cytoplasmic ratio, nuclear hyperchromatism and prominent nucleoli, keratinized squamous cells with pyknotic nuclei, foreign body giant cells, and chronic inflammatory cells in necrotic background. Retrospective view of this aspiration smear revealed that these findings were characteristic features of pilomatrixoma, and the evenly distributed chromatin pattern as well as the lack of nuclear pleomorphism were considered to be the differential points from malignant neoplasm. Pilomatrixoma is a benign neoplasm which should be included in differential diagnosis if the fine needle aspiration cytologic smear of a neck mass or subcutaneous mass of any site showed these features.
Adult
;
Azathioprine
;
Biopsy, Fine-Needle
;
Chromatin
;
Diagnosis, Differential
;
Female
;
Giant Cells, Foreign-Body
;
Hodgkin Disease
;
Humans
;
Lymph Nodes
;
Neck
;
Nephritis
;
Pilomatrixoma
;
Reed-Sternberg Cells
;
Retrospective Studies
;
Young Adult
8.Knowledge of human papillomavirus infection and acceptability of vaccination among adult women in Korea.
Kyoung A CHOI ; Jung Hye KIM ; Kyoung Soon LEE ; Jin Kyoung OH ; Shan Ni LIU ; Hai Rim SHIN
Korean Journal of Obstetrics and Gynecology 2008;51(6):617-623
OBJECTIVE: The HPV vaccination target adolescents, and may be influenced by opinion of parents and other family member. For implementation of HPV vaccine, we measured knowledge of HPV infection and acceptability of vaccination among adults in Korea. METHODS: From August 2006 to November 2007, we provided a written questionnaire to females (above 19 years- olds) who visited Il-sin Christian hospital for prenatal care or gynecological examination. The questionnaire was built using elements of The Health Belief Model. We measured (1) awareness of HPV (2) perceived susceptibility (3) perceived seriousness (4) perceived benefit of vaccination (5) perceived barriers (6) cues to action. RESULTS: Total 975 females answered the questionnaire, and the mean age was 40 years. Only 23.8% knew the fact cervical cancer is related to HPV infection. 78.3% of respondents were willing to accept HPV vaccination after they understood HPV vaccination can prevent cervical cancer. Financial burden and possible side effect were barriers to vaccination. CONCLUSIONS: Despite of low awareness of HPV infection, most (78.3%) adults favored having HPV vaccination. But the vaccine was more likely to be accepted if it is recommended by a physician and reasonably priced.
Adolescent
;
Adult
;
Cues
;
Surveys and Questionnaires
;
Female
;
Gynecological Examination
;
Humans
;
Korea
;
Papillomavirus Infections
;
Parents
;
Prenatal Care
;
Uterine Cervical Neoplasms
;
Vaccination
9.A Case of Skin Metastasis from Mucoepidermoid Carcinoma of Parotid Gland Mimicking Radiodermatitis.
Kyoung Jin KIM ; Sung Eun CHANG ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 2001;13(3):171-174
Cutaneous metastasis from parotid gland carcinoma is very rare and there have been no re-ports in Korean literatures. Furthermore, it can often manifest as inflammatory type of skin metastasis and mimic a radiodermatitis. We report a case of a 31-year-old Korean man with cutaneous metastasis originated from parotid gland mucoepidermoid carcoinoma which mimicked clinically a radiodermatitis.
Adult
;
Carcinoma, Mucoepidermoid*
;
Humans
;
Neoplasm Metastasis*
;
Parotid Gland*
;
Radiodermatitis*
;
Skin*
10.A Case of Acrodermatitis Continua of Hallopeau.
Hae Woong LEE ; Kyoung Jin KIM ; Mi Woo LEE ; Jee Ho CHOI ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 2004;16(3):141-143
No abstract available.
Acrodermatitis*