OBJECTIVES: This study was performed to investigate the relationship between age of onset in late-life depression and T2 hyperintensities observed in the brain MRI, we tried to see part of pathophysiology of late-life depression. METHOD: The subjects consisted of 18 patients whose first depressive episode occurred before age 50, and 20 patients whose first depressive episode occurred after age 50 years, and 20 agematched controls. Depressive patients were diagnosed according to DSM-IV. Established hyperintensity rating systems were used to analyse the T2 weighted images and blood pressure, cholesterol level, DM, EKG were measured to compare the relationships. RESULTS: 1) Signal hyperintensities on T2 weighted image were more severe in late-life depressive patients whose first depressive episode after age 50 (p<0.05) and there is no significant difference between patients whose first episode before age 50 and age-matched control subjects. 2) Mild signal hyperintensities were observed in all elderly depressed patients and control subjects, but severe hyperintensities were observed in late-onset depression. 3) Signal hyperintensities were related to age, hypertension, blood cholesterol level (p<0.05). CONCLUSION: The late onset depressive patients had more white matter hyperintensities on T2 weighted image than early onset depressive patients. this results support previous hypothesis that white matter change is the important biological factor of late-onset elderly depression and old age, hypertension, hypercholesterolemia may be associated with signal hyperintensities.
Age of Onset ; Aged ; Biological Factors ; Blood Pressure ; Brain* ; Cholesterol ; Depression ; Diagnostic and Statistical Manual of Mental Disorders ; Electrocardiography ; Humans ; Hypercholesterolemia ; Hypertension ; Magnetic Resonance Imaging*

No abstract available.
Epidemiology*

No abstract available.
Aneurysm, Infected* ; Endocarditis* ; Mesenteric Artery, Superior*

The preservation of fertility in female cancer survivors has become an important health issue. The different cryopreservation options available for fertility preservation are embryo, oocyte, and ovarian tissue cryopreservation. Oocyte cryopreservation is available for women without partners, but there is a limited experience with this technique and the pregnancy rate is still low. In spite of recent reports of successful birth after autotransplantation of cryopreserved-thawed human ovarian cortical tissues, clinical experience is also limited and this technique remains still experimental. Whole ovary cryopreservation itself poses several challenges. Further researches for establishing optimal cryopreservation and thawing protocols and increasing post-thawing survival, pregnancy, and delivery rates are necessary. In this article, the strategies for fertility preservation in cancer survivors are discussed. The different options and their results are discussed, as well as their indications, efficacy and ethical issues.
Cryopreservation ; Embryonic Structures ; Female ; Fertility ; Fertility Preservation ; Humans ; Oocytes ; Ovary ; Parturition ; Pregnancy ; Pregnancy Rate ; Survivors

We had experienced a case of congenital lobar emphysema in a 3 months old male infant. Chief symptoms included tachypenea, respiratory difficulty, cyanosis, Chest X-ray or chest CT scan revealed extensive emphysematous changes of the right upper and middle lobes, compression of the right lower lobe and shifted of mediastinum to the left side. This condition was appeared in the absence of infection and foreign body in the bronchus and its failure to respond to conservative treatment. This patient was treated by the right upper and right middle lobes pneumonectomy. A brief review of literature was made.
Bronchi ; Cyanosis ; Emphysema ; Foreign Bodies ; Humans ; Infant ; Male ; Mediastinum ; Pneumonectomy ; Thorax ; Tomography, X-Ray Computed

We had experienced a case of congenital lobar emphysema in a 3 months old male infant. Chief symptoms included tachypenea, respiratory difficulty, cyanosis, Chest X-ray or chest CT scan revealed extensive emphysematous changes of the right upper and middle lobes, compression of the right lower lobe and shifted of mediastinum to the left side. This condition was appeared in the absence of infection and foreign body in the bronchus and its failure to respond to conservative treatment. This patient was treated by the right upper and right middle lobes pneumonectomy. A brief review of literature was made.
Bronchi ; Cyanosis ; Emphysema ; Foreign Bodies ; Humans ; Infant ; Male ; Mediastinum ; Pneumonectomy ; Thorax ; Tomography, X-Ray Computed

BACKGROUND/AIMS: Non-tuberculous Mycobacterium (NTM) infections usually result in chronic disease, and making a diagnosis is often difficult. Skin and soft tissue infections due to NTM are not common and are usually diagnosed relatively late. We investigated the clinical characteristics of nine cases of skin and soft tissue infections with NTM. METHODS: Nine patients with an NTM infection who were confirmed consecutively by skin and soft tissue and/or adjacent bone cultures at a teaching hospital between August 2006 and July 2013 were enrolled in this study. The demographics, clinical characteristics, underlying diseases, treatment, and prognosis between different NTM species were reviewed retrospectively. RESULTS: The most common NTM species causing a soft tissue infection was Mycobacterium abscessus (five patients, 55.6%). Common sites of infection were the knee and lumbar spine. Five patients (55.6%) had underlying diseases. Six patients (77.8%) were treated with combined surgical treatment (incision and drainage) plus antibiotics. The duration from symptom onset to diagnosis was long (77.7 +/- 44.6 days) due to inadequate microbiological evaluation and disregard for the clinical significance of the NTM culture. All patients were cured with treatment; however, the treatment duration was long (181.7 +/- 140.0 days). Procedure and cosmetic surgery were the most important risk factors for infection. CONCLUSIONS: The diagnosis of NTM skin and soft tissue infections tends to be delayed in a clinical setting. Therefore, a high index of suspicion for NTM infection in chronic localized soft tissue infections is essential for diagnosis. Mycobacterium abscessus appears to be the most common NTM species causing soft tissue infections.
Anti-Bacterial Agents ; Chronic Disease ; Demography ; Diagnosis ; Hospitals, Teaching ; Humans ; Knee ; Mycobacterium Infections ; Mycobacterium* ; Prognosis ; Retrospective Studies ; Risk Factors ; Skin ; Skin Diseases ; Soft Tissue Infections* ; Spine ; Surgery, Plastic

Vitamin K is a naturally-occurring vitamin used to treat certain coagulation disorders. Despite its frequent use, vitamin K causes allergic reactions very rarely. We report a case of anaphylaxis due to vitamin K (phytonadione) that occurred in a 20-year-old man who has undergone hemorrhoid bleeding. The patient developed immediate whole body urticaria, itching sensation, dyspnea and marked hypotension about 2 minutes after the intravenous administration of vitamin K (phytonadione) and tranexamic acid for the purpose of bleeding control. Skin prick test was performed with vitamin K and tranexamic acid. Vitamin K showed positive response in skin prick test, while tranexamic acid showed negative response in skin prick test and challenge test. To our knowledge, it is the first case report of vitamin K-induced anaphylaxis that is proven with skin test. This case suggests that vitamin K can elicit anaphylaxis and skin test may be helpful in the diagnosis of a suspected allergic response to vitamin K.
Administration, Intravenous ; Anaphylaxis* ; Diagnosis ; Drug Hypersensitivity ; Dyspnea ; Hemorrhage ; Hemorrhoids ; Humans ; Hypersensitivity ; Hypotension ; Pruritus ; Sensation ; Skin ; Skin Tests ; Tranexamic Acid ; Urticaria ; Vitamin K ; Vitamins* ; Young Adult

PURPOSE: Leptomeningeal cyst or growing skull fracture can occur in young infants or children following head trauma. We present MR imaging findings in five children with growing skull fracture. MATERIALS AND METHODS: We reviewed the MR images of five children (M: F=2:3) with growing skull fracture. The mean age was 7.5 years. The time interval between the occurrence of head trauma and the presentation of growing skull fracture varied from three months to 12 years. We reviewed the precontrast CT scans and/or the plain skull radiographs in those patients for whom these studies were available. RESULTS: The most common location of the growing skull fracture was the parietal bone (n=3). On the MR images, there were bone defects with posttraumatic cystic encephalomalacia or porencephalic cysts. Marginal bony thickening and diploic space widening were noted in four patients. MR imaging was excellent for visualizing the parenchymal changes and pericranial lesions. CONCLUSION: In children with growing skull fracture, MR imaging can clearly depict trauma-related parenchymal changes, pericerebral lesions as well as bony edge thickening with remodeling.
Arachnoid Cysts ; Child ; Craniocerebral Trauma ; Encephalomalacia ; Humans ; Infant ; Magnetic Resonance Imaging ; Parietal Bone ; Skull Fractures ; Skull ; Tomography, X-Ray Computed

PURPOSE: Leptomeningeal cyst or growing skull fracture can occur in young infants or children following head trauma. We present MR imaging findings in five children with growing skull fracture. MATERIALS AND METHODS: We reviewed the MR images of five children (M: F=2:3) with growing skull fracture. The mean age was 7.5 years. The time interval between the occurrence of head trauma and the presentation of growing skull fracture varied from three months to 12 years. We reviewed the precontrast CT scans and/or the plain skull radiographs in those patients for whom these studies were available. RESULTS: The most common location of the growing skull fracture was the parietal bone (n=3). On the MR images, there were bone defects with posttraumatic cystic encephalomalacia or porencephalic cysts. Marginal bony thickening and diploic space widening were noted in four patients. MR imaging was excellent for visualizing the parenchymal changes and pericranial lesions. CONCLUSION: In children with growing skull fracture, MR imaging can clearly depict trauma-related parenchymal changes, pericerebral lesions as well as bony edge thickening with remodeling.
Arachnoid Cysts ; Child ; Craniocerebral Trauma ; Encephalomalacia ; Humans ; Infant ; Magnetic Resonance Imaging ; Parietal Bone ; Skull Fractures ; Skull ; Tomography, X-Ray Computed